Human trophoblasts confer resistance to viruses implicated in perinatal infection
نویسندگان
چکیده
منابع مشابه
Human placental trophoblasts confer viral resistance to recipient cells.
Placental trophoblasts form the interface between the fetal and maternal environments and serve to limit the maternal-fetal spread of viruses. Here we show that cultured primary human placental trophoblasts are highly resistant to infection by a number of viruses and, importantly, confer this resistance to nonplacental recipient cells by exosome-mediated delivery of specific microRNAs (miRNAs)....
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During mammalian pregnancy, the placenta acts as a barrier between the maternal and fetal compartments. The recently observed association between Zika virus (ZIKV) infection during human pregnancy and fetal microcephaly and other anomalies suggests that ZIKV may bypass the placenta to reach the fetus. This led us to investigate ZIKV infection of primary human trophoblasts (PHTs), which are the ...
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ژورنال
عنوان ژورنال: American Journal of Obstetrics and Gynecology
سال: 2015
ISSN: 0002-9378
DOI: 10.1016/j.ajog.2014.07.060